Pack size: 1 Capsule  |  Price is for the whole Capsule

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Temozolomide Hydrochloride

Form: Capsule 250mg

Indication

Glioblastoma multiforme, Malignant gliomas, Metastatic melanoma

Administration

Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before meals. Swallow capsules whole with a full glass of water on an empty stomach or at bedtime. Do not take a 2nd dose if capsules are vomited.

Adult Dose

$48

Child Dose

Oral Recurrent or progressive malignant gliomas Child: >3 yr: Previously untreated with chemotherapy: 200 mg/m2 once daily for 5 days, followed by a 23 day break (1 cycle). Previously treated with chemotherapy: 150 mg/m2 daily for 5 days followed by 23 day break (1 cycle) increased to 200 mg/m2 for the 2nd cycle if there is no haematological toxicity.

Contraindication

Hypersensitivity to dacarbazine. Severe myelosupression. Pregnancy.

Mode of Action

Temozolomide, a triazene, is an inactive prodrug. It is chemically hydrolysed to 3-methyl-(triazen-1-yl) imidazole-4-carboxamide (MTIC), the active metabolite of dacarbazine. The cytotoxicity of MTIC is believed to be due alkylation of DNA, mainly at the O6 and N7 positions of guanine.

Introduction

$4a

Uses of __NAME__

{'list': ['Brain tumor']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Nausea', 'Vomiting', 'Constipation', 'Headache', 'Fatigue', 'Convulsion', 'Coordination disorder', 'Diarrhea', 'Dizziness', 'Fever', 'Hair loss', 'Hemiparesis (weakness on one side of the body)', 'Insomnia (difficulty in sleeping)', 'Loss of appetite', 'Memory loss', 'Rash', 'Viral infection', 'Weakness']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. __NAME__ is to be taken empty stomach.

How __NAME__ works

__NAME__ is an anti-cancer medication. It enters the brain tissues and works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

__NAME__ is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor. Cautious use is advised in patients with severe kidney disease while they are taking __NAME__.

Safety Advice

__NAME__ should be used with caution in patients with severe liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Limited information is available on the use of __NAME__ in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.