Abeclib 150 (Box of 10)

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৳9,500.00

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৳9,500.00

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Detail Description

Pack size: Box of 10 Tablets | Price is for the whole Box

Generic: Abemaciclib

Form: Tablet 150mg

Indication

Breast Cancer

Administration

May take with or without food Instruct patient to take dose at approximately the same time each day

Adult Dose

Breast Cancer Indicated for HR+/HER2- advanced or metastatic breast cancer with disease progression following endocrine therapy as either monotherapy or in combination with fulvestrant Also, indicated in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women with HR+/HER2- advanced or metastatic breast cancer Monotherapy 200 mg PO BID Continue until disease progression or unacceptable toxicity Combination therapy With aromatase inhibitor Abemaciclib: 150 mg PO BID PLUS Aromatase inhibitor: See Prescribing Information Continue until disease progression or unacceptable toxicity With fulvestrant Abemaciclib: 150 mg PO BID PLUS Fulvestrant: 500 mg IM on Days 1, 15, and 29, and then once monthly thereafter Continue until disease progression or unacceptable toxicity Hepatic impairment Mild or moderate (Child-Pugh A or B): No dose adjustment required Severe (Child-Pugh C): Reduce dosing frequency to once daily

Renal Dose

Renal impairment Mild or moderate (CrCl 30-89 mL/min): No dose adjustment required Severe, ESRD, or dialysis: Not studied

Mode of Action

Inhibits cyclin-dependent kinases (CDKs) 4 and 6 These kinases are activated upon binding to D cyclins and play a crucial role in signaling pathways, which lead to cell cycle progression and cellular proliferation In ER-positive breast cancer cells, cyclin D1 and CDK4/6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation

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