Pack size: 1 Syrup  |  Price is for the whole Syrup

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Zidovudine

Form: Syrup 50mg/5ml

Indication

Cancer therapy-induced hyperuricaemia, HIV infection

Administration

May be taken with or without food. IV Preparation Dilute to not to exceed 4 mg/mL w/ D5W IV Administration Infuse over 1 hr

Adult Dose

HIV Infection 300 mg PO q12hr OR 200 mg PO q8hr (600 mg/day) IV: 1 mg/kg/dose 5-6x/day Maternal Dosing to Prevent Fetal HIV Transmission FDA-approved regimen 100 mg PO 5x/day until start of labor, in combination with other ART agents During labor and delivery: 2 mg/kg IV over 1 hr, THEN 1 mg/kg/hr IV continuous infusion until umbilical cord clamping NIH perinatal guidelines Indicated during labor and delivery for women who have received antepartum ART and their HIV RNA levels are >400 copies/mL, or in women who have not received antepartum ART 2 mg/kg IV loading dose infused over 1 hr, THEN 1 mg/kg/hr until umbilical cord clamping Women who have received antepartum ART and their HIV RNA levels are <400 copies/mL do not require IV zidovudine Hepatic Impairment Reduction in daily dose or extension of dosing interval may be necessary

Child Dose

HIV Infection, Treatment 4 weeks-18 years 240 mg/m² PO q12hr or 160 mg/m² PO q8hr, OR use mg/kg dosing 4 to <9 kg: 12 mg/kg PO q12hr or 8 mg/kg PO TID > 9 to <30 kg: 9 mg/kg PO q12hr or 6 mg/kg PO TID >30 kg: 300 mg PO q12hr or 200 mg PO TID IV intermittent infusion: 120 mg/m² IV q6h IV continuous infusion: 20 mg/m²/hr IV HIV Perinatal Transmission Prevention Indicated to prevent mother-to-child HIV transmission in all HIV-exposed infants FDA approved regimen 2 mg/kg PO q6hr or 1.5 mg/kg IV q6hr NIH perinatal guidelines <30 weeks’ gestation: 2 mg/kg PO or 1.5 mg/kg IV BID; after age 4 weeks, advance to 3 mg/kg PO or 2.3 mg/kg IV q12hr >30 to <35 weeks’ gestation: 2 mg/kg PO BID; after age 15 days, advance to 3 mg/kg PO or 2.3 mg/kg IV q12hr >35 weeks’ gestation: 4 mg/kg PO or 3 mg/kg IV BID x6 weeks

Renal Dose

Renal Impairment CrCl < 15 mL/min (maintained on hemodialysis or peritoneal dialysis): 100 mg PO or 1 mg/kg IV q6-8 hr; alternatively 100 mg PO qDay or 300 mg/day PO

Contraindication

Hypersensitivity; abnormally low neutrophil counts (<0.75 x 109/L) or Hb levels (<7.5 g/dL or 4.65 mmol/L); newborn infants w/ hyperbilirubinaemia requiring treatment other than phototherapy, or w/ increased transaminase levels >5 times the ULN. Lactation. Concomitant use w/ interferon alfa (w/ or w/o ribavirin) in HIV and hepatitis B or C virus co-infected patients.

Introduction

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Uses of __NAME__

{'list': ['HIV infection']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Fatigue', 'Headache', 'Decreased appetite', 'Nausea', 'Vomiting', 'Muscle pain']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

Caution is advised when consuming alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

__NAME__ should be used with caution in patients with severe kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with moderate to severe liver disease.