Pack size: 1 Tablet  |  Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Capecitabine

Form: Tablet 500mg

Indication

Breast cancer, Colorectal cancer, Gastric cancer, Oesophageal cancer

Administration

Swallow with water within 30 min after a meal

Adult Dose

Oral Breast cancer; Colorectal cancer Adult: 1.25 g/m2 bid for 2 wk followed by a 1 wk rest period; therapy to be given in 3-wk cycles. Recommended treatment duration for colorectal cancer: 6 mth. May be used in combination with docetaxel at 75 mg/m2, given as a 1-hr IV infusion once every 3 wk for the treatment of breast cancer. Gastric cancer Adult: Used in combination with a platinum-based compound, 1 g/m2 bid for 14 days, followed by a 7-day rest period. 1st dose is given on the evening of day 1 and the last dose on the morning of day 15.

Renal Dose

Renal impairment: CrCl (ml/min) 51-80 No adjustment needed. 30-50 Reduce dose to 950 mg/m2 bid when starting dose is 1.25 g/m2 bid. No dose adjustment is needed when starting dose is 1 g/m2. <30 Avoid use.

Contraindication

History of severe and unexpected reactions to fluoropyrimidine therapy; severe renal impairment; pregnancy, lactation. Hypersensitivity.

Mode of Action

Capecitabine is a prodrug that is converted to fluorouracil following oral administration, which in turn inhibits thymidylate synthetase, blocking the methylation of deoxyuridylic acid to thymidylic acid, interfering with DNA, and to a lesser degree, RNA synthesis.

Introduction

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Uses of __NAME__

{'list': ['Breast cancer', 'Cancer of colon and rectum']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Vomiting', 'Weakness', 'Nausea', 'Abdominal pain', 'Diarrhea', 'Blisters on fingers/feet']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ is to be taken with food.

How __NAME__ works

__NAME__ is an anticancer medication. Inside the body, this medicine gets converted into 5-fluorouracil (chemical). This chemical hampers the synthesis of genetic materials (RNA and DNA) in the cancer cells, thereby interferes with their growth. This slows down the growth of cancer cells and eventually kills them.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with severe kidney disease.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with severe kidney disease.