Pack size: 1 Injection  |  Price is for the whole Injection

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Vinblastine

Form: Injection 10mg/vial

Indication

Histiocytic lymphoma, Hodgkin's disease, Kaposi's sarcoma, Letterer-Siwe disease, Lymphocytic lymphoma, Mycosis fungoides, Testicular cancer

Administration

IV Preparation IV push 1 mg/mL (dose/syringe); max syringe size for IVP is a 30 mL syringe & syringe should be <75% full Powder: reconstitute w/ 10 mL NS or bacteriostatic NS to obtain 1 mg/mL soln Continuous infusion: 250-1000 mL D5W or NS (dose)

Adult Dose

Intravenous Cancers Testicular CA, Squamous cell CA of head & neck, Hodgkin's Dz, Kaposi's sarcoma; histiocytic lymphoma, mycosis fungoides, & Letterer-Siwe disease (histiocytosis X) General Dosing Ranges 3.7-18 mg/sq.meter/day IV q7-10d 1st dose 3.7 mg/sq.meter/day IV Incr by 1.85 mg/sq.meter qweek until WBC equal 3000/cu.mm NMT 18.5 mg/sq.meter Hepatic impairment Decrease dose by half if bilirubin >3 mg/dL [>51 umol/L]

Child Dose

Intravenous Cancers Testicular CA, Squamous cell carcinoma CA of head & neck, Hodgkin's Dz, Kaposi's sarcoma; histiocytic lymphoma, mycosis fungoides, & Letterer-Siwe disease (histiocytosis X) General dosing ranges 2.5- 12.5 mg/sq meter IV q7-10d 1st dose 2.5 mg/sq.meter IV Incr by 1.25 mg/sq.meter qWeek until WBC = 3000/cu.mm No more than 12.5 mg/sq.meter

Contraindication

Severe bone marrow suppression; presence of bacterial infection; maglignant cell infiltration of bone marrow; Inj into extremity with poor circulation; porphyria; granulocytopenia. Elderly with cachexia or extreme skin ulcerations. Pregnancy; lactation. Intrathecal use may result in death.

Mode of Action

Vinblastine is M phase specific. It binds to microtubular proteins and arrests mitosis at the metaphase by disrupting mitotic spindle formation. It blocks glutamic acid utilization, thus inhibiting purine synthesis, the citric acid cycle, and the formation of urea. It may also interfere with nucleic acid and protein synthesis.

Introduction

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Uses of __NAME__

{'list': ['Breast cancer', 'Kidney cancer', 'Hodgkin’s disease', 'Non-Hodgkin's lymphoma']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Nausea', 'Vomiting', 'Decreased appetite', 'Decreased white blood cell count', 'Diarrhea']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How __NAME__ works

__NAME__ blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive.

Safety Advice

__NAME__ is safe to use in patients with kidney disease. No dose adjustment of __NAME__ is recommended. However, talk to your doctor if you have any underlying kidney disease.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ may not be advised in patients with severe liver disease.