Pack size: 1 500mg vial  |  Price is for the whole 500mg vial

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Thiopental Sodium

Form: Injection 500mg

Indication

Status epilepticus, Induction of anesthesia, Reduction of raised intracranial pressure

Adult Dose

Intravenous Induction of anaesthesia Adult: 100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg. Status epilepticus Adult: In conjunction with assisted ventilation: 75-125 mg as a 2.5% solution. Reduction of raised intracranial pressure Adult: Intermittent bolus inj of 1.5-3.5 mg/kg, if adequate ventilation is provided. Elderly: Dose reduction may be needed. Hepatic impairment: Dose reduction may be needed.

Child Dose

Intravenous Induction of anaesthesia Child: 2-7 mg/kg over 10-15 seconds; repeated after 1 minute if needed.. Status epilepticus Child: 5 mg/kg by slow IV inj followed by, neonates: continuous iv infusion of 2.5 mg/kg/hr; >1 month: 2-8 mg/kg/hr. Adjust infusion dose according to response. Reduction of raised intracranial pressure Child: 3 mth-15 yr: initial 5-10-mg/kg IV followed by a continuous IV infusion at 1-4 mg/kg/hr.

Renal Dose

Renal impairment: Dose reduction may be needed.

Contraindication

Thiopental Sodium for Injection is contraindicated in patients with severe respiratory embarrassment, hypersensitivity to barbiturates, status asthmaticus, variegate or acute intermittent porphyria, and inflammatory conditions of the mouth, jaw, and neck and in the absence of suitable veins for intravenous administration. Thiopental Sodium for Injection is also relatively contraindicated in severe cardiovascular disease, hypotension or shock, and conditions in which the hypnotic effect may be prolonged or potentiated, i.e. excessive premedication, Addison's disease, hepatic or renal dysfunction, myxedema, increased blood urea, severe anemia and myasthenia gravis.

Mode of Action

Thiopental sodium, a short-acting barbiturate anaesthetic, is a CNS depressant inducing hypnosis and anaesthesia but not analgesia. It has also been used in the control of refractory tonic-clonic status epilepticus and to reduce increased intracranial pressure in neurosurgical patients.

Introduction

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Uses of __NAME__

{'list': ['Anesthesia']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Injection site reactions (pain, swelling, redness)', 'Drowsiness', 'Skin rash', 'Nausea', 'Vomiting', 'Diarrhea', 'Vertigo']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How __NAME__ works

__NAME__ is a general anaesthetic. It works by causing reversible loss of consciousness to allow surgery without pain and distress.

Safety Advice

It is unsafe to consume alcohol with __NAME__.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.