Pack size: Strip of 10 Tablets  |  Price is for the whole Strip

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Tamoxifen

Form: Tablet 20mg

Indication

Breast cancer

Administration

May be taken with or without food.

Adult Dose

Oral Breast Cancer Treatment 20 mg daily as a single or in 2 divided doses. Max: 40 mg daily. Continue with adjuvant therapy for at least 5 years For women with ER-positive disease, continuing tamoxifen to 10 years rather than stopping at 5 years produces a further reduction in recurrence and mortality, particularly after year 10 Breast Cancer Prevention Indicated to reduce the incidence of breast cancer in women at high risk for breast cancer; high risk is defined as women aged >35 years with a 5-year predicted risk of breast cancer >1.67% (calculated by the Gail Model) Adult: 20 mg daily for 5 yr. Data are limited for use >5 yr in the risk-reduction setting Anovulatory infertility Adult: 20 mg daily on days 2-5 of the menstrual cycle, increase if necessary in subsequent cycles. Max: 80 mg daily. Women w/ irregular menstruation: Initial course may begin on any day and a 2nd course may start 45 days later.

Contraindication

History of DVT or pulmonary embolism. Pregnancy and lactation. Concomitant coumarin-type anticoagulant therapy.

Mode of Action

Tamoxifen, a triphenylethylene derivative, produces a nuclear complex by competitively binding to oestrogen receptors on tumours and other tissue targets thus, decreasing DNA synthesis and inhibiting oestrogen effect. It is only cytostatic rather than cytotoxic due to accumulation of cell in G0 and G1 phases.

Precaution

Patient w/ leucopenia and thrombocytopenia, hyperlipidaemias. Monitoring Parameters Perform periodic CBC (e.g. platelet counts) and LFTs. Routine gynaecological monitoring and any abnormal symptoms (e.g. abnormal vag bleeding or discharge, pelvic pain, menstrual irregularities). Lactation: not known if excreted in breast milk, do not nurse

Introduction

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Uses of __NAME__

{'list': ['Breast cancer']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Nausea', 'Skin rash', 'Hot flashes', 'Thinning of hair', 'Vaginal discharge', 'Swelling']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is a hormone-based medication. It works by binding to estrogen receptors and blocking the effects of estrogen (a natural female hormone) in the breast tissue. This slows down the growth and multiplication of breast cancer cells.

Safety Advice

It is unsafe to consume alcohol with __NAME__.

Safety Advice

__NAME__ is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Safety Advice

__NAME__ is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. __NAME__ may cause tiredness. This may affect your driving ability.

Safety Advice

__NAME__ is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.

Safety Advice

There is limited information available on the use of __NAME__ in patients with liver disease. Please consult your doctor.