Pack size: 1 Injection  |  Price is for the whole Injection

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Neostigmine Methyl Sulphate

Form: Injection 500mcg/ml

Indication

Myasthenia gravis, Paralytic ileus, Post-op urinary retention, Reversal of nondepolarising neuromuscular blockade

Adult Dose

Parenteral Myasthenia gravis Adult: 0.5-2.5 mg by IM or SC inj, doses are given at intervals according to response up to a total daily dose of 5-20 mg. Paralytic ileus and postoperative urinary retention Adult: 0.5-2.5 mg by SC or IM inj, as required. Reversal of neuromuscular blockade Adult: 0.03-0.07 mg/kg by inj over 60 sec, as required. Not to exceed 0.07 mg/kg or a cumulative total of 5 mg, whichever dose is less Inject by slow IV over at least 1 minute

Child Dose

Parenteral Myasthenia gravis Child: <12 yr 0.2-0.5 mg, repeated at suitable intervals throughout the day. Paralytic ileus and postoperative urinary retention Child: 0.125-1 mg by SC or IM inj. Intravenous Reversal of neuromuscular blockade Child: 0.05-0.07 mg/kg by inj over 60 sec, as required. Intramuscular Neonatal myasthenia gravis Child: Initially, 0.1 mg, followed by 0.05-0.25 mg or 0.03 mg/kg 2-4 hrly.

Renal Dose

Renal impairment: Dose adjustment may be required.

Contraindication

Mechanical GI or urinary tract obstruction, peritonitis.

Mode of Action

Neostigmine reversibly inhibits acetylcholinesterase and thus potentiates the nicotinic and muscarinic effects of acetylcholine. This facilitates the transmission of impulses across myoneural junction.

Introduction

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Uses of __NAME__

{'list': ['Myasthenia gravis', 'Paralytic ileus', 'Post-operative urinary retention', 'Reversal of effect of skeletal muscle relaxant after surgery']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Nausea', 'Vomiting', 'Abdominal cramp', 'Diarrhea']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is a reversible cholinesterase inhibitor. When taken by mouth it increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (enzyme). This acetylcholine further triggers muscle contracting receptors which helps in muscle contraction.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Safety Advice

__NAME__ may cause excessive drowsiness with alcohol.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Safety Advice

It is not known whether __NAME__ alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Regular monitoring of kidney function test and some blood tests may advised while you are taking this medicine.

Safety Advice

__NAME__ is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.