Pack size: 1 5ml drop  |  Price is for the whole 5ml drop

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Hydrocortisone + Neomycin Sulphate + Polymixin B E/E prep

Form: Eye Drop

Indication

Ocular inflammation, Otitis externa

Adult Dose

Ophthalmic Ocular inflammation with suspected or confirmed bacterial infection Adult: 1-2 drops every 3-4 hrly as indicated. Otic/Aural Otitis externa Adult: As combination containing neomycin sulfate 3.5 mg as neomycin base, polymyxin B sulfate 10,000 units, hydrocortisone 10 mg (1%) per ml: Instill 4 drops into affected ear 3-4 times daily; instill drop with the affected ear upward and remain in this position for 5 minutes. Alternatively insert a cotton wick into the canal and saturate wick with solution, add solution every 4 hr to keep wick moist and replace wick at least once daily.

Child Dose

Otic/Aural Otitis externa Child: 2-16 yr: As combination containing neomycin sulfate 3.5 mg as neomycin base, polymyxin B sulfate 10,000 units, hydrocortisone 10 mg (1%) per ml: Instill 3 drops into affected ear 3-4 times daily; instill drop with the affected ear upward and remain in this position for 5 minutes. Alternatively insert a cotton wick into the canal and saturate wick with solution, add solution every 4 hr to keep wick moist and replace wick at least once daily.

Contraindication

Hypersensitivity to aminoglycosides and any of its components. Pre-existing nerve deafness. TB, fungal or viral infections. Do not use in external eardrum if tympanic membrane is perforated.

Mode of Action

Neomycin, an aminoglycoside with spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many Gram-negative aerobes and some strains of staphylococci. Polymyxin B disrupts bacterial cell membrane and has bactericidal action against most Gram-negative bacilli. It is inactive against Gram-positive bacteria, obligate anaerobes and Neisseria spp. When used together, they are active against Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella-Enterobacter species, Neisseria species, and Pseudomonas aeruginosa but have inadequate coverage against Serratia marcescens and streptococci, including Streptococcus pneumoniae. Hydrocortisone, a corticosteroid with mainly glucocorticoid activity, suppresses inflammatory response.

Precaution

Ophthalmic: Glaucoma; monitor intraocular pressure regularly if used for >10 days. Otic: Limit use to ≤10 days to reduce risk of ototoxicity. May cause burning and stinging if product enters the middle ear.