Pack size: 1 10mg vial  |  Price is for the whole 10mg vial

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Cisplatin

Form: Injection 1mg/ml

Indication

Lymphomas, Sarcomas, Carcinomas, Small cell lung cancer, Ovarian cancer, Germ cell tumors, Metastatic Testicular Tumors, Metastatic Ovarian Tumors, Advanced Bladder Cancer

Administration

IV Preparation Further dilution stability is dependent on chloride ion concentration & should be mixed in solutions of NS (at least 0.3% NaCl) Further dilution in NS, D5/½NS or D5/NS to a concentration of 0.05-2 mg/mL are stable for 72 hr at 4-25°C in combination with mannitol May administer 12.5-50 g mannitol/L Standard dilution: dose/250-1000 mL NS, D5W/NS or D5/½NS IV Administration Perform pretreatment hydration Do not use aluminum-containing needles or IV administration sets that may come in contact with carboplatin (aluminum can react causing precipitate formation & loss of potency) Administration rate has varied from a 15-120 min infusion, 1 mg/min infusion, 6-8 hr infusion, 24 hr infusion, or per protocol Maximum rate of infusion: 1 mg/min in patients with CHF When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before platinum derivatives to limit myelosuppression & to enhance efficacy

Adult Dose

$48

Renal Dose

Renal Impairment CrCl 10-50 mL/min: Decrease dose 50% CrCl <10 mL/min: Contraindicated

Contraindication

Patients with severe renal or auditory disorder, known hypersensitivity, severe bone marrow suppression, peripheral neuropathy, pregnancy, lactation.

Mode of Action

Cisplatin modifies cell cycle by interfering with DNA structure and function. Effects are most prominent during the S phase but cells are killed at all stages. Cisplatin synergises with other anticancer drugs e.g. fluorouracil. It has a narrow therapeutic margin and is highly toxic.

Introduction

$4a

Uses of __NAME__

{'list': ['Ovarian cancer', 'Cervical cancer', 'Testicular cancer']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Injection site reactions (pain, swelling, redness)', 'Increased risk of infection', 'Ear disorder', 'Vomiting', 'Nausea', 'Decreased blood cells (red cells, white cells, and platelets)', 'Renal impairment', 'Peripheral neuropathy (tingling and numbness of feet and hand)', 'Kidney damage', 'Hearing loss', 'Ringing in ear']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

How __NAME__ works

__NAME__ is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, please consult your doctor.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. __NAME__ may cause side effects such as feeling sleepy and/or vomiting which could affect your ability to drive.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Use of __NAME__ is not recommended in patients with severe kidney disease.

Safety Advice

__NAME__ is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.