Pack size: Box of 10 Tablets  |  Price is for the whole Box

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Flibanserin

Form: Tablet 100mg

Indication

Indicated for premenopausal women with acquired, generalized, hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not caused by a coexisting medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance,

Adult Dose

Hypoactive Sexual Desire Disorder Indicated for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not caused by a coexisting medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance 100 mg PO once daily at bedtime Dosed at bedtime because administration during waking hours increases risks of hypotension, syncope, accidental injury, and CNS depression Discontinued after 8 weeks if no improvement

Contraindication

Use with alcohol Co-administration with moderate or strong CYP3A4 inhibitors Any degree of hepatic impairment

Mode of Action

Postsynaptic serotonin-1A (5HT-1A) receptor agonist and 5HT-2A receptor antagonist; also elicits moderate antagonist activities at the 5-HT2B, 5-HT2C, and dopamine D4 receptors The mechanism of action HSDD is not known; may work by restoring prefrontal cortex control over the brain's motivation/rewards structures, enabling sexual desire to manifest; this may occur by increasing dopamine and norepinephrine while transiently decreasing serotonin in the brain's prefrontal cortex, which may be accomplished by reduced glutamate transmission

Precaution

$4b

Side Effect

>10% Dizziness (11.4%) Somnolence (11.2%) Nausea (10.4%) 1-10% Fatigue (9.2%) Insomnia (4.9%) Dry mouth (2.4%) Anxiety (1.8%) Constipation (1.6%) Abdominal pain (1.5%) Metrorrhagia (1.4%) Rash (1.3%) Sedation (1.3%) Vertigo (1%)