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Detail Description

Pack size: 1 10ml drop  |  Price is for the whole 10ml drop

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops

Form: Ear Drops 500mg+100mg/100ml

Indication

Acute bacterial ear infections

Adult Dose

Otic/Aural Otitis externa Adult: Instill 2-3 drops into the ear bid-tid.

Contraindication

History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the eye or ear, mycosis.

Mode of Action

Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae. Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.

Precaution

Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.

Side Effect

Ear drops: Ototoxicity.

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