Navafil 50

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৳50.00

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Detail Description

Pack size: 1 Tablet | Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Avanafil

Form: Tablet 50mg

Indication

Erectile Dysfunction

Administration

May take with or without food

Adult Dose

Erectile Dysfunction 100 mg PO initially as early as 15 min before sexual activity; not to exceed 1 dose/day Based on individual efficacy and tolerability, the dose may be increased to 200 mg taken as early as ~15 minutes before sexual activity, or decreased to 50 mg taken ~30 minutes before sexual activity Use lowest effective dose Hepatic impairment Mild to moderate impairment: Dose adjustment not necessary Severe impairment: Safety and efficacy not established; do not use

Renal Dose

Renal Impairment Mild-to-moderate (CrCl ?30 mL/min): Dose adjustment not necessary Severe impairment (CrCl 15-29 mL/min): Safety and efficacy not established; do not use

Contraindication

Hypersensitivity Soluble guanylate cyclase (sGC) stimulators (eg, riociguat); concomitant use can cause hypotension

Mode of Action

Sexual stimulation causes nitric oxide to be released in the corpus cavernosum; nitric oxide activates the enzyme guanylate cyclase, which in turn increases cGMP levels; increase in cGMP levels causes smooth muscle relaxation. Phosphodiesterase type 5 inhibitors enhance the effects of nitric oxide in smooth muscle relaxation of the corpus cavernosum by inhibiting the degradation of cGMP.