Pack size: 1 Tablet  |  Price is for the whole Tablet

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Imatinib

Form: Tablet 100mg

Indication

Chronic myeloid leukaemia, Acute lymphoblastic leukaemia, Myelodysplastic disease, Hypereosinophilic syndrome, Mastocytosis, Dermatofibrosarcoma protuberans, Malignant gastrointestinal stromal tumours

Administration

Should be taken with food and large glass of water.

Adult Dose

$4a

Child Dose

Chronic Myeloid Leukemia Indicated for newly diagnosed adult and pediatric patients with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase <1 year: Safety and efficacy not established >1 year: 340 mg/m²/day PO; not to exceed 600 mg/day Acute Lymphoblastic Leukemia Indicated for treatment of newly diagnosed children with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) <1 year: Safety and efficacy not established >1 year: 340 mg/m²/day PO; not to exceed 600 mg/day

Contraindication

Hypersensitivity. Lactation.

Mode of Action

Imatinib, is a tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase created by the Philadelphia chromosome abnormality in chronic myeloid leukaemia (CML). It blocks proliferation and induces apoptosis in BCR-ABL positive cell lines, as well as fresh leukaemic cells from Philadelphia chromosome positive CML. Imatinib also inhibits receptor kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-kit, PDGF- and SCF-mediated cellular events.

Introduction

$4b

Uses of __NAME__

{'list': ['Blood cancer (Chronic myeloid leukaemia)', 'Blood cancer (Acute lymphocytic leukemia)', 'Gastrointestinal stromal tumour']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Abdominal pain', 'Diarrhea', 'Fatigue', 'Muscle cramp', 'Musculoskeletal (bone, muscle or joint) pain', 'Nausea', 'Rash', 'Vomiting']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ is to be taken with food.

How __NAME__ works

__NAME__ is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, skip it and continue with your normal schedule. Do not double the dose.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Lactating women should not breastfeed while using this drug and one month after stopping it.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with severe liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.