Pack size: Strip of 10 Tablets  |  Price is for the whole Strip

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Dasatinib

Form: Tablet 140mg

Indication

Chronic myeloid leukaemia

Administration

May be taken with or without food. Swallow whole, do not break/crush/cut.

Adult Dose

Oral Chronic myeloid leukaemia Adult: Chronic phase CML: Initially, 100 mg once daily, may increase up to 140 mg once daily. Accelerated, myeloid or lymphoid blast phase CML or Philadelphia chromosome-positive ALL: Initially, 140 mg once daily, may increase up to 180 mg once daily. Hepatic impairment: No dosage adjustment needed.

Contraindication

Concomitant use w/ CYP3A4 inhibitors (e.g. atazanavir, clarithromycin, erythromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole or grapefruit juice); CYP3A4 inducers (e.g. carbamazepine, dexamethasone, phenytoin, phenobarbital, rifampicin or St John's wort); antacid. Pregnancy.

Mode of Action

Dasatinib is an inhibitor of multiple tyrosine kinases. It is used for the treatment of all phases of chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL) in adults who have resistance or intolerance to previous therapy, including imatinib.

Precaution

Patients w/ predisposing factors for QT prolongation (e.g. congenital long QT syndrome, hypokalaemia, hypomagnesaemia, on antiarrhythmic therapy, or receiving cumulative high doses of anthracyclines). Hepatic impairment. Lactation. Monitoring Parameters Evaluate patients for manifestations of underlying cardiopulmonary disease prior to and during therapy. Measure full blood counts wkly for the 1st 2 mth and then mthly thereafter. Lactation: not known if excreted in breast milk; do not nurse

Introduction

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Uses of __NAME__

{'list': ['Blood cancer (Chronic myeloid leukaemia)']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Abdominal pain', 'Anemia (low number of red blood cells)', 'Breathing problems', 'Fatigue', 'Fever', 'Headache', 'Infection', 'Low blood platelets', 'Musculoskeletal (bone, muscle or joint) pain', 'Nausea', 'Rash', 'Vomiting']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ may be taken with or without food, but it is better to take it at a fixed time.

How __NAME__ works

__NAME__ is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, skip it and continue with your normal schedule. Do not double the dose.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. Take special care when driving in case you experience side effects such as dizziness and blurred vision with __NAME__.

Safety Advice

__NAME__ is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of __NAME__ may not be needed in these patients. Please consult your doctor.

Safety Advice

__NAME__ is safe to use in patients with liver disease. No dose adjustment of __NAME__ is recommended.