Pack size: 1 500mg Vial  |  Price is for the whole 500mg Vial

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Cytarabine

Form: injection 500mg/ml

Indication

Acute myeloid leukaemia, acute lymphocytic leukaemia (ALL), lymphomas, Leukaemic meningitis

Administration

IV Administration Rapid IV, infusion over 1-3 hr, or SC intrathecal Has been administered by IM & continuous SC infusion IT: Patient should lie flat for 1 hour after lumbar puncture Liposomal: To reduce incidence of arachnoiditis, administer dexamethasone concurrently IV Preparation Reconstitute vials in BWI containing benzyl alcohol 0.945% as follows (CAUTION: Do not use benzyl alcohol for intrathecal inj) 100 mg vial: add 5 mL diluent to 20 mg/mL 500 mg vial: add 10 mL diluent to 50 mg/mL 1 g vial: add 10 mL diluent to 100 mg/mL 2 g vial: add 20 mL diluent to 100 mg/mL

Adult Dose

Acute Nonlymphocytic Leukemia IV administration for remission induction 100-200 mg/sq.meter/day for 5-10 days; begin second course in 2-4 weeks after initial therapy if necessary OR 100 mg/sq.meter for 7 days OR 100 mg/sq.meter/dose q12hr for 7 days Intrathecal (IT) administration for remission induction 5-75 mg/sq.meter q2-7Days until CNS findings normalize IV administration for remission maintenance 70-200 mg/sq.meter/day for 2-5 days at monthly intervals IM administration for remission maintenance 1-1.5 mg/kg single dose for maintenance at 1- 4 week intervals Meningeal Leukemia IT administration 30 mg/sq.meter intrathecal (IT) q4Days until CSF findings normal plus one additional dose Refractory Leukemia IV administration 3 g/sq.meter IV (infusion over 1-3 hours) q12hr x 4-12 doses Repeat q2-3Weeks

Contraindication

Hypersensitivity; pregnancy and lactation.

Mode of Action

Cytarabine acts by interfering with DNA synthesis specifically at the S-phase of the cell cycle. It is a potent myelosuppressant and requires careful haematological monitoring during its use. It also has antiviral property.

Precaution

Hepatic and renal dysfunction, severe infections, preexisting drug-induced bone marrow suppression. Monitor WBC, platelet counts and blood uric acid frequently. Assess renal and hepatic function periodically. Lactation: not known if excreted in breast milk, avoid

Introduction

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Uses of __NAME__

{'list': ['Blood cancer']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Rash', 'Skin ulcer', 'Nausea', 'Vomiting', 'Hair loss', 'Abdominal pain', 'Anal ulcers', 'Anemia (low number of red blood cells)', 'Decreased white blood cell count', 'Fever', 'Infection', 'Abnormal liver function', 'Low blood platelets', 'Mouth ulcer', 'Pneumonia', 'Sepsis', 'Mouth sore', 'Stomatitis (Inflammation of the mouth)']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How __NAME__ works

__NAME__ interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.

Safety Advice

It is not known whether it is safe to consume alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive.

Safety Advice

__NAME__ is safe to use in patients with kidney disease. No dose adjustment of __NAME__ is recommended. However, talk to your doctor if you have any underlying kidney disease.

Safety Advice

There is limited information available on the use of __NAME__ in patients with liver disease. Please consult your doctor. Because of the limited information, a cautious use of __NAME__ is recommended in patients with liver disease.