The active ingredients i.e. the antioxidants present in each tablet, namely Vitamin A, Vitamin C & Vitamin E have been linked with reduced risks of cardiovascular diseases in human. All of these three antioxidant vitamins have also been linked with reduced risks of cataract. Supplementation with ... Read more

The active ingredients i.e. the antioxidants present in each tablet, namely Vitamin A, Vitamin C & Vitamin E have been linked with reduced risks of cardiovascular diseases in human. All of these three antioxidant vitamins have also been linked with reduced risks of cataract. Supplementation with Vitamin E shows to reduce the susceptibility of blood lipoproteins (the proteins that carry cholesterol in the blood) to oxidation, which is the major causative factor in the formation of atheromata in the walls of blood vessels. Vitamin E also helps protect the immune system and hence to combat infection and chronic diseases.

Vitamin E may also be of value in reversing the age-related trend toward decreased competence of the immune system, as well as other age-related degenerative changes.

Vitamin C plays an important part in the response of the body to stress. It is important in the defense against infection. Vitamin C possesses some anti-inflammatory activity and protects cells against oxidative damage to essential molecules. Vitamin C increases iron absorption.

The primary role of Vitamin E is the prevention of oxidation of polyunsaturated fatty acids. Vitamin E reacts with free radicals which are the cause of oxidative damage to cell membranes, without the formation of another free radical in the process.

Dosage & Administration

This tablet is administered orally. The adult dose of this combination of antioxidant vitamin tablet is 1 tablet daily or as prescribed by the physician.

Interaction

There is no potentially hazardous drug interactions with retinol (after conversion of beta carotene to it). Both cadmium and copper decreases retinol plasma levels. Among antibiotics, neomycin, and bleomycin reduces the absorption of retinol.

Vitamin C is incompatible in solution with aminophylline, bleomycin, erythromycin, lactobionate, nafcillin, nitrofurantoin sodium, conjugated oestrogens, sodium bicarbonate, sulphafurazole diethanolamine, chloramphenicol sodium succinate, chlorothiazide sodium and hydrocortisone sodium succinate. It increases the apparent half-life of paracetamol and enhances iron absorption from the gastro-intestinal tract.

Contraindications

Although human body converts Beta Carotene to Vitamin A only when required, yet excessive doses of Vitamin A should be avoided in pregnancy because of potential teratogenic effects. Patients with hypersensitivity to retinol should not take this preparation, although the possibility of such cases are occasional. Vitamin C in megadoses has been contraindicated for
patients with hyperoxaluria. A pregnant woman taking more than 5 gm daily ascorbate may suffer fetal abortion. Higher doses of Vitamin C have been reported to cause failure of conception. In case of Vitamin E, there are no absolute contraindication.

Side Effects

Loose stools may occasionally occur during treatment with beta carotene and the skin may assume a slightly yellow discoloration. The toxic eects of vitamin A (after conversion of beta carotene to it) which are encountered are normally reversible and an irreversible toxic effect is effectively unknown. Chronic overdosage can lead to peeling and redness of the skin, disturbed hair growth, loss of appetite, and sickness.

Vitamin C is usually well tolerated. Large doses are reported to cause diarrhoea and other gastro-intestinal disturbances. It has also been stated that doses may result in hyperoxaluria and the formation of renal calcium oxalate calculi and it should therefore be given with care to patients with hyperoxaluria.

Vitamin E is usually well tolerated. Large doses may cause diarrhoea, abdominal pain, and other gastro-intestinal disturbances, and have also been reported to cause fatigue and weakness.

Precautions & Warnings

There are some evidences that β carotene may cause harm to heavy smokers and alcoholics. Therefore, caution should be exercised in these cases. Vitamin C should be given with caution to patients with hyperoxaluria. Vitamin E should be used with caution in patients taking anticoagulant drugs, because vitamin E may enhance the anticoagulant activity of these drugs.

Therapeutic Class

Anti-oxidant Multivitamin preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.