Pack size: Strip of 10 Tablets  |  Price is for the whole Strip

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Vericiguat

Form: Tablet 5mg

Indications

Vericiguat is indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.

Pharmacology

Vericiguat is a stimulator of soluble guanylate cyclase (sGC), an important enzyme in the nitric oxide (NO) signaling pathway. When NO binds to sGC, the enzyme catalyzes the synthesis of intracellular cyclic guanosine monophosphate (cGMP), a second messenger that plays a role in the regulation of vascular tone, and cardiac contractility, and cardiac remodeling. Heart failure is associated with impaired synthesis of NO and decreased activity of sGC, which may contribute to myocardial and vascular dysfunction. By directly stimulating sGC, independently of and synergistically with NO, vericiguat augments levels of intracellular cGMP, leading to smooth muscle relaxation and vasodilation.

Dosage & Administration

$4b

Interaction

Other Soluble Guanylate Cyclase Stimulators: Vericiguat is contraindicated in patients with concomitant use of other soluble guanylate cyclase (sGC) stimulators.

PDE-5 Inhibitors: Concomitant use of Vericiguat with PDE-5 inhibitors is not recommended because of the potential for hypotension.

With food & others: Vericiguat should be taken with food. The absolute bioavailability of Vericiguat is 93% when taken with food.

Contraindications

Vericiguat is contraindicated in patients with concomitant use of other soluble guanylate cyclase (sGC) stimulators.

Side Effects

Common Side effects: The most common side effects of Vericiguat tablet include low blood pressure & low red blood cells (Anemia).

Uses

Vericiguat tablet is used to treat adults who are experiencing a recent worsening of long-term heart failure symptoms.