Pack size: 1 5gm tube  |  Price is for the whole 5gm tube

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Bacitracin Zinc + Neomycin Sulphate + Polymixin B Eye prep

Form: Eye Ointment

Indication

Bacterial ocular infections

Adult Dose

Adult: Eye Drop: 1-2 drops 3-4 times daily. Eye ointment: Apply 1/2 inch ribbon of ointment to conjunctival sac of affected eye(s) q3-4hr for 7-10 days for acute infections

Child Dose

Child: Eye Drop: 1-2 drops 3-4 times daily. Eye ointment: Apply 1/2 inch ribbon of ointment to conjunctival sac of affected eye(s) q3-4hr for 7-10 days for acute infections

Contraindication

Hypersensitivity

Mode of Action

Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci. Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents. Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids.

Precaution

Excessive use of the topical preparation may lead to substantial systemic absorption which may lead to nephrotoxicity (polymyxin B sulfate) and neurotoxicity (bacitracin). Prolonged use of the antibacterial preparation may cause overgrowth of non-susceptible organisms, including fungi. Pregnancy and lactation. Lacation: Excretion in breast milk unknown; caution