Pack size: 1 Injection  |  Price is for the whole Injection

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Bortezomib

Form: Injection 2mg/vial

Indication

Mantle Cell Lymphoma, Multiple Myeloma,

Administration

IV or SC Preparation Reconstitute vial with 0.9% NaCl IV administration: Add 3.5 mL to vial for final concentration of 1 mg/mL SC administration: 2.5 mg/mL: Add 1.4 mL to vial for final concentration of 2.5 mg/mL If local injection site reactions occur following SC administration, a less concentrated solution (1 mg/mL) may be administered subcutaneously IV or SC Administration Not for intrathecal (IT) use; inadvertent IT has resulted in death and is contraindicated Separate consecutive doses by at least 72 hr Give IV as a bolus over 3-5 seconds or as SC injection Give SC injection in thigh or abdomen; rotate injection site with each dose Monitor hydration status Use cytotoxic handling procedures for preparation, administration, and disposal

Adult Dose

$4b

Contraindication

Hypersensitivity. Child. Pregnancy and lactation.

Mode of Action

Bortezomib is a reversible inhibitor of the chymotrypsin-like activity of the 26-S proteasome. It prevents targeted proteolysis that affects multiple signaling cascades responsible for normal homeostatic functions within the cell, leading to cell death.

Precaution

Hepatic or renal impairment; history of syncope, orthostatic hypotension; dehydration. Impairs ability to drive or operate machinery. Monitor for symptoms of peripheral neuropathy. Monitor closely the blood glucose levels in patients receiving oral antidiabetic agents.

Introduction

$4c

Uses of __NAME__

{'list': ['Multiple myeloma', 'Mantle-cell lymphoma']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Low blood platelets', 'Fatigue', 'Peripheral neuropathy (tingling and numbness of feet and hand)', 'Psychiatric disturbances', 'Nausea', 'Vomiting', 'Loss of appetite', 'Fever', 'Anemia (low number of red blood cells)', 'Diarrhea', 'Decreased appetite', 'Decreased white blood cell count (neutrophils)', 'Constipation']}

How to use __NAME__

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How __NAME__ works

__NAME__ is an anti-cancer medication. It works by blocking or slowing the breakdown of proteins in cells. As a result, there is an increase in a number of proteins in the cancer cells leading to their death.

What if you forget to take __NAME__?

If you miss a dose of __NAME__, please consult your doctor.

Safety Advice

__NAME__ may cause excessive drowsiness with alcohol.

Safety Advice

__NAME__ is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Safety Advice

__NAME__ is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Safety Advice

__NAME__ may cause side effects which could affect your ability to drive. __NAME__ might cause tiredness, dizziness, fainting, or blurred vision which may affect your ability to drive.

Safety Advice

__NAME__ should be used with caution in patients with severe kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor. Limited information is available on the use of __NAME__ in these patients.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.