Pack size: 1 Injection  |  Price is for the whole Injection

⚠ Prescription required. This medicine may only be dispensed against a valid prescription.

Generic: Aminophylline

Form: Injection 125mg/5ml

Indication

Oral Chronic bronchospasm Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary. Intravenous Acute severe bronchospasm Adult: Loading dose: 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow inj or infusion over 20-30 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min. Elderly: Dose reduction may be ncessary. Hepatic impairment: Dose reduction may be ncessary.

Administration

Other xanthines. Clearance reduced by allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon-alpha, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, cigarette smoking. Corticosteroids, diuretics, beta2-agonists. Potentially Fatal: Increased risk of cardiac arrhythmias with sympathomimetics and halothane. Tachycardia with pancuronium. beta-blockers inhibit metabolism. Increased risk of convulsion with quinolones, ketamine.

Adult Dose

Neonates, elderly, lactation, pregnancy, cardiac/hepatic diseases, peptic ulceration, hyperthyroidism, hypertension, epilepsy, heart failure, chronic alcoholism, acute febrile illness.

Renal Dose

Aminophylline is a combination of theophylline and ethylenediamine. Ethylenediamine is inactive; it increases the solubility of theophylline in water. Theophylline relaxes bronchial smooth muscle. Suggested mechanisms are an increase in intracellular cAMP through inhibition of phosphodiesterase; adenosine receptor antagonism, prostaglandin antagonism and effects on intracellular calcium.

Contraindication

Oral Chronic bronchospasm Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk. Intravenous Acute severe bronchospasm Child: Loading dose: same as adult dose. Maintenance dose: 6 mth-9 yr: 1 mg/kg/hr and 10-16 yr: 0.8 mg/kg/hr.

Mode of Action

Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.

Introduction

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Uses of __NAME__

{'list': ['Asthma', 'Chronic obstructive pulmonary disease (COPD)']}

Side effects of __NAME__

{'tag': 'Common', 'list': ['Headache', 'Insomnia (difficulty in sleeping)', 'Vomiting', 'Nausea']}

How to use __NAME__

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. __NAME__ is to be taken empty stomach.

How __NAME__ works

__NAME__ is a bronchodilator. It works by relaxing the muscles of the airways and widens airways. This makes breathing easier.

Safety Advice

Caution is advised when consuming alcohol with __NAME__. Please consult your doctor.

Safety Advice

__NAME__ may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Safety Advice

__NAME__ is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Safety Advice

__NAME__ does not usually affect your ability to drive.

Safety Advice

__NAME__ should be used with caution in patients with kidney disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.

Safety Advice

__NAME__ should be used with caution in patients with liver disease. Dose adjustment of __NAME__ may be needed. Please consult your doctor.