Generic: Acyclovir Topical  |  Dosage Form: Cream  |  Manufacturer: Aristopharma Ltd.

Indications

Acyclovir cream is indicated for the treatment of initial and recurrent labial and genital Herpes simplex infections. Treatment should begin as early as possible.

Dosage & Administration

Acyclovir cream should be applied to lesions 5 times daily for 5-10 days. The affected area should be kept clean and dry; patients should be instructed to wear loose-fitting clothing to avoid irritation to the lesion.

Safety and effectiveness in pediatric patients less than 12 years of age have not been established.

Interaction

Clinical experience has identified no interactions resulting from topical or systemic administration of other drugs concomitantly with Acyclovir cream. Due to minimal systemic absorption of Acyclovir cream, systemic drug interactions are unlikely.

Contraindications

Acyclovir cream is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.

Side Effects

The most common adverse reactions at the site of topical application were dry lips, desquamation, dryness of skin, cracked lips, burning skin, pruritus, flakiness of skin, and stinging on skin; each adverse reaction occurred in less than 1% of patients receiving Acyclovir cream and placebo. Three patients on Acyclovir cream and one patient on placebo discontinued treatment due to an adverse event.

Precautions & Warnings

Acyclovir cream should only be applied on the affected external aspects of the lips and face in patients with herpes labialis. Because no data are available, application to human mucous membranes is not recommended. Acyclovir cream is intended for cutaneous use only and should not be used in the eye or inside the mouth or nose. Cream has a potential for irritation and contact. The effect of Acyclovir cream has not been established in immunocompromised patients.

Therapeutic Class

Topical Antiviral preparations

Storage Conditions

Store Acyclovir cream at room temperature between 20°C to 25°C